2015 Fiscal Year Final Research Report
The physiological and biochemical studies of short-lasting memory
| Project/Area Number |
25430029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
UENO Kohei 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (40332556)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ショウジョウバエ / 神経可塑性 / ドパミン |
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| Outline of Final Research Achievements |
The physiological and structural changes upon synapses are underlying memory formation. Recent studies suggest that dopamine plays important role for the plastic change. However it is unclear which molecular pathway is activated by dopamine and how dopamine is released during memory formation. Previously, I successfully induced plastic change in the synaptic transmission between olfactory central and mushroom body, olfactory memory core, in the isolated Drosophila brain. We used the isolated brain system and found that dopamine signaling phosphorylates various molecules in the mushroom body. Moreover, we found that dopamine release during memory formation is regulated not only dopaminergic neurons but also mushroom body neurons.
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| Free Research Field |
神経科学
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