Developmental process of cerebellar compartmentalization and topographic axonal projections as basis for cerebellar functional localization

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: SUGIHARA Izumi 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (60187656)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マウス / 小脳 / 縦縞状区画構造 / Pcdh10 / レポーターマウス / 形成過程 / プルキンエ細胞

Outline of Final Research Achievements

We analyzed the process of formation of the cerebellar compartmentalization and topographic axonal projection, which are important for varieties of cerebellar functions such as the control of many motor activities. Seven compartments elongated in the rostrocaudal direction were recognized in the early cerebellum at the embryonic day 14.5 (E14.5). The process in which these compartments were separated and divided into some 50 compartments in three days by E17.5 was clarified in the three-dimensional space. It was also observed that topographic axonal connection was formed first in the cerebellar nuclei, which then leads to compartmentalization. Results obtained in the related research projects were published in five research papers in international academic journals with the principal investigator as the corresponding author during the three-year period of the grant support. However, some central results are still under preparation for publication.

Free Research Field

神経科学