Targeted disruption of a gene that encodes a signaling molecule for a neurite branching.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25430033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute for Physiological Sciences (2015-2016); Niigata University (2013-2014)
• Principal Investigator: Kishi Masashi 生理学研究所, 生体機能調節研究領域, 特別協力研究員 (60573938)
• Research Collaborator: FURUSE Mikio 生理学研究所, 生体機能調節研究領域, 教授 ; NAGAOKA Tadahiro 生理学研究所, 生体機能調節研究領域, 特別協力研究員
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経突起 / 蛋白質リン酸化 / 行動解析

Outline of Final Research Achievements

A protein kinase called BrancK expressed in the mouse brain was analyzed in vivo. Targeted disruption of BrancK in mice revealed that this molecule is important for normal formation and branching of the neurites of the neurons of the central and peripheral nervous systems. We further analyzed morphological, behavioral, and biochemical defects of the mutant mice, and identified a disease phenotype and binding proteins. These results shed light on the role for a protein kinase signaling in the development of human brain and psychiatric diseases.

Free Research Field

神経発生