2016 Fiscal Year Final Research Report
Expression and functional roles of HMGB family in adult neurogenesis
| Project/Area Number |
25430039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto Prefectural University of Medicine (2016)
Fukushima Medical University (2013-2015) |
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Principal Investigator |
Imura Tetsuya 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00405276)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 神経幹細胞 / 神経新生 |
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| Outline of Final Research Achievements |
HMGB2, a member of high-mobility group box protein (HMGB) family, is selectively expressed in adult neurogenic regions. Neural stem cells and neural progenitors highly express HMGB2, but its expression disappears after neuronal maturation. Knockdown and forced expression of HMGB2 indicate that it regulates survival and maturation of newborn cells.
We also identify that nuclear orphan receptor Nr4a2 is highly expressed in embryonically-generated, but not in adult-generated granule cells, in hippocampal dentate gyrus. Nr4a2 expression in granule cells is linked to environmental stress exposure, suggesting its role in neurogenesis-related stress response and memory formation.
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| Free Research Field |
神経科学
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