2015 Fiscal Year Final Research Report
Role of local protein synthesis regulated by Fragile X Mental Retardation Protein during presynapse formation
Project/Area Number |
25430068
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Yokohama City University |
Principal Investigator |
SASAKI Yukio 横浜市立大学, 生命医科学研究科, 准教授 (10295511)
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Co-Investigator(Renkei-kenkyūsha) |
KAWAKAMI Takao 横浜市立大学, 生命医科学研究科, 客員准教授 (40366117)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 横浜市 / 神経生物学 / 脆弱X症候群 / シナプス / プロテオミクス |
Outline of Final Research Achievements |
To investigate to a role of local protein synthesis during presynapse differentiation in neurons, we identified proteins that accumulate in axons during presynapse differentiation. Most of the identified proteins are derived from the target mRNA for FMRP (Fragile X Mental Retardation Proteins), the RNA-binding protein. Among these proteins, we examined Munc-18 accumulation during the presynapse differentiation. The accumulation time-course of Munc-18 corresponded to that of Argonaute2 (Ago2), which interacts with FMRP. Thus, it is possible that FMRP-Ago2 complex regulate Munc-18 expression via local protein synthesis during presynapse differentiation.
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Free Research Field |
神経生物学
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