2015 Fiscal Year Final Research Report
Analysis and regulation of bi-directional changes in maturation status of brain cells utilising in vitro hightrokghput assay system
| Project/Area Number |
25430077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAKAWA Tsuyoshi 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 細胞成熟度 / 海馬 / 歯状回 / 統合失調症 / うつ病 |
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| Outline of Final Research Achievements |
We sought to determine the molecular basis of the bi-directional changes in maturation status of brain cells, utilising primary mouse hippocampal (dentate gyrus) cultures as the in vitro hightrokghput assay system. Bioinformatics was also applied for the analysis and we identified several signal molecules that can be involved in the bi-directional changes. We next screened for biological conditions that are able to lead to the changes in cellular maturation status, identifying treatments of several chemicals that may induce the maturation status changes.
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| Free Research Field |
神経科学
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