Effects of the modulation of the innate immunity and Dock family member on multiple sclerosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: GUO Xiaoli 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 主任研究員 (50443114)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: グリア細胞

Outline of Final Research Achievements

We examined the effects of ASK1, one of the stress response genes, on the severity of the clinical score and optic neuritis in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Clinical signs of EAE were mild in glia-specific ASK1 conditional knockout mice. We also examined the effect of Dock8, an atypical guanine nucleotide exchange factor, on EAE, and found that optic neuritis was mild in Dock8 deficient mice.

Free Research Field

神経科学