2015 Fiscal Year Final Research Report
Analysis of bone formation activity during pregnancy by in vivo imaging
| Project/Area Number |
25430088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATSUZAWA Kiyotaka 鳥取大学, 医学部, 教授 (20256655)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | オステオカルシン / 妊娠 / ルシフェラーゼ / 骨形成 |
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| Outline of Final Research Achievements |
In OC-Luc mice, expressing luciferase under the control human osteocalcin (OC) promoter, luminescence increased bimodally during pregnancy. TRAP activity and blood concentration of estrogen/progesterone showed positive correlation with luminescence increase during pregnancy. However, expression of endogenous mouse OC decreased and did not correlate with the rise of luminescence derived from OC-Luc during pregnancy. Luminescence derived from OC-Luc was also expressed in placenta, where no expression of mouse OC has been detected. These results show that human OC promoter was controlled differently from mouse OC promoter, suggesting that OC-Luc mice reflects the human OC expression during pregnancy.
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| Free Research Field |
発生工学
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