2015 Fiscal Year Final Research Report
Analysis of anti-tumor activity of interleukin-9 in melanoma models.
| Project/Area Number |
25430096
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Chubu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | メラノーマ / IL-9 |
|---|
| Outline of Final Research Achievements |
We investigated whether IL-9 play an anti-melanoma activity in a RET-transgenic mouse, a spontaneous melanoma model. Previous study reported that IL-9 mediates tumor immunity to melanoma using a B16F10 mouse melanoma model. Our results indicated that in vivo administration of IL-9 did not suppress the spontaneous melanoma, though intratumoral accumulation of some granulocytes were observed. In addition, IL-9 also did not exert anti-tumor activity in a nude mice transplanted with B16F10. We concluded that administration of IL-9 failed to prevent a spontaneous melanoma progression in RET-transgenic mice, but IL-9 may potentiate anti-tumor activity mediated by T cell and granulocytes function.
|
| Free Research Field |
分子免疫学
|
