2015 Fiscal Year Final Research Report
Mechanisms of senescence-resistance of the naked mole-rat
| Project/Area Number |
25430116
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Hokkaido University (2014-2015)
Keio University (2013) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MIURA KYOKO 北海道大学, 遺伝子病制御研究所, 講師 (80583062)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | ハダカデバネズミ / 細胞老化 / 細胞死 |
|---|
| Outline of Final Research Achievements |
The naked mole-rat (NMR) is a long-living rodent with the maximum lifespan exceeding 30 years. Moreover, NMR has “senescence-resistant” and “cancer-resistant” phenotypes. In this study, to elucidate NMR’s “senescence-resistant” mechanisms at the cellular level, we subjected NMR skin fibroblasts to cellular senescence stimuli and compared their phenotypes with those of mouse. We found that NMR cells underwent cell death rather than cellular senescence. Moreover, we found the responsible gene for cell death in NMR cells after induction of cellular senescence. We also induced cellular senescence in skins of living NMRs. Compared to mice, we found that senescent cells were rarely detected in NMR’s skin.
|
| Free Research Field |
発生工学
|
