Identification and characterization of mitochondrial regulators modulating the unfolded protein response

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430120
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: KUNIMASA KAZUHIRO 公益財団法人がん研究会, その他部局等, 研究員 (50534020)
• Co-Investigator(Renkei-kenkyūsha): TOMIDA AKIHIRO 公益財団法人がん研究会, がん化学療法センター ゲノム研究部, 部長 (40251483)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん微小環境 / 小胞体ストレス応答 / グルコース飢餓 / ミトコンドリア / オートファジー

Outline of Final Research Achievements

We focused on the unfolded protein response (UPR) that are induced by tumor microenvironmental stresses such as glucose starvation, and screened the novel UPR regulators to develop effective cancer chemotherapy under tumor microenvironment. Using a siRNA focused library and functional analyses, several candidates for the UPR modulator were identified. Furthermore, we found a novel UPR inhibitor and characterized its potential mode of action via gene expression signature- and chemosensitivity-based approaches.

Free Research Field

腫瘍生物学、腫瘍治療学