Regulation of tumor microenvironment by tumor-associated sialyl-Tn antigen

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Sapporo Medical University
• Principal Investigator: Takamiya RIna 札幌医科大学, 医学部, 助教 (70365419)
• Co-Investigator(Kenkyū-buntansha): Ohtsubo Kazuaki 熊本大学, 大学院生命科学研究部(保), 教授 (30525457)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 低酸素 / 糖鎖抗原 / マクロファージ

Outline of Final Research Achievements

The expression of sialyl-Tn (sTn) antigen abnormally expresses in several types of cancers, is often related to poor prognosis and tumor metastasis. However, the relevance of the sTn antigen expression to tumor progression is yet to be determined. The expression of sTn-expressing tumor cells coincided with HIF-1 expressing cells in solid tumor tissues. Furthermore, macrophages and T cells partially infiltrated into solid tumor, where specifically expressed sTn antigen. In addition, sialyl-Tn antigen on integrin induced the adhesion of tumor cells to monocytes. These results suggest that sTn antigen may trigger tumor progression by modifying of immune microenvironment, especially macrophage function.

Free Research Field

細胞生物学