2016 Fiscal Year Final Research Report
Pathological evaluation for advanced colorectal cancer aiming at treatment proposal for molecular targeted drugs
| Project/Area Number |
25430136
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Tumor diagnostics
|
|---|
| Research Institution | Osaka Medical College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | 大腸癌 / 分子標的薬 / 病理評価 / EGFR / HER3 / 腫瘍内不均一性 |
|---|
| Outline of Final Research Achievements |
Comparative studies of immunostaining of EGFR and HER3 in advanced colorectal cancer showed that the expression pattern of HER3 at the invasive margin tended to be opposite to that of EGFR. Pathological assessment of immunostaining requires careful consideration of the heterogeneity within the tumor, otherwise it may not accurately reflect the biological properties of tumors and hence the therapeutic effect.
|
| Free Research Field |
病理学
|
