2016 Fiscal Year Final Research Report
Development of novel pancreatic cancer diagnostic and therapeutic method targeting Annexin A8
| Project/Area Number |
25430141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Nihon University (2016)
Showa University (2013-2015) |
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Principal Investigator |
HATA Harumi 日本大学, 薬学部, 准教授 (00396441)
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| Co-Investigator(Kenkyū-buntansha) |
立道 昌幸 東海大学, 医学部, 教授 (00318263)
小林 秀昭 帝京平成大学, 薬学部, 教授 (90344069)
町田 昌明 星薬科大学, 薬学部, 准教授 (80421212)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | Annexin A8 |
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| Outline of Final Research Achievements |
Pancreatic cancers demonstrate the worst prognosis of all the major cancers. Therefore, we must find effective markers for early diagnosis and/or identify novel molecular therapeutic targets. We clarified that changes in expression levels of ANXA8 were associated with anticancer drug sensitivity in cancer cell lines, and that ANXA8 was secreted extracellularly in pancreatic cancer cell lines.
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| Free Research Field |
衛生学
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