2015 Fiscal Year Final Research Report
Development of estrogen receptor degrader and analysis of drug-induced cell death mechanism for breast cancer therapy
| Project/Area Number |
25430164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | The University of Tokushima (2014-2015)
National Institute of Health Sciences (2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
DEMIZU Yosuke 国立医薬品食品研究所, 有機化学部, 室長 (90389180)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 乳癌 / エストロゲン受容体 |
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| Outline of Final Research Achievements |
Recently, we have developed a hybrid small molecule named SNIPER(ER) (Specific and Non-genetic IAP-dependent Protein Eraser for Estrogen Receptor) that induces degradation of estrogen receptor alpha (ERa) proteins via ubiquitin-proteasome system. In this study, we revealed that SNIPER(ER) induces ROS production after the ERa degradation and caused necrotic cell death of MCF-7 cells, implying a therapeutic potential of SNIPER(ER) as a lead for the treatment of ERa-positive breast cancers.
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| Free Research Field |
細胞生物学
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