Study on the epigenetic regulation of metabolic programming and energy homeostasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430178
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical genome science
• Research Institution: Kumamoto University
• Principal Investigator: Hino Shinjiro 熊本大学, 発生医学研究所, 助教 (00448523)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヒストン脱メチル化 / エネルギー代謝 / 骨格筋 / がん代謝 / クロマチン

Outline of Final Research Achievements

The purpose of this study was to explore the epigenetic mechanisms that underpin the metabolic programming in response to environmental stress. We focused on the molecular function and the biological roles of histone demethylases LSD1 and LSD2. We found that LSD1 was involved in the fiber type determination of skeletal muscle and that it also plays an essential role in the glycolytic shift in cancer cells. LSD2 was involved in the protection of hepatocytes from lipotoxic cell damage.
We also investigated the behavior of biosynthetic enzymes for FAD, which is a essential coenzyme of LSD1 and LSD2. We found that FAD synthesis enzymes exhibited a unique subcellular localization, indicating that LSD1 and LSD2 might interact with FAD in a specific region in the cell.
Altogether, our study indicates that LSD1 and LSD2 serve as molecular hubs that transmit environmental information into epigenenomic modifications.

Free Research Field

エピジェネティクス