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2016 Fiscal Year Final Research Report

X-ray crystallographic study of Bloom syndrome helicase BLM and its role in prevention of tumorigenesis.

Research Project

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Project/Area Number 25440024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Kitano Ken  奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40346309)

Project Period (FY) 2013-04-01 – 2017-03-31
KeywordsX線構造解析 / ブルーム症候群 / ヘリカーゼ / ホリデイジャンクション / タンパク質 / DNA
Outline of Final Research Achievements

Bloom syndrome is a rare cancer-predisposition disorder caused by mutations of the Bloom syndrome protein (BLM). In this study, structural and biochemical studies of human BLM helicase were performed. New information about the reaction mechanism of BLM helicase toward Holliday junction (a repair intermediate in the DNA double-stranded break repair) was obtained.

Free Research Field

構造生物学

URL: 

Published: 2018-03-22  

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