2016 Fiscal Year Final Research Report
X-ray crystallographic study of Bloom syndrome helicase BLM and its role in prevention of tumorigenesis.
| Project/Area Number |
25440024
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Nara Institute of Science and Technology |
|---|
Principal Investigator |
Kitano Ken 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (40346309)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | Ｘ線構造解析 / ブルーム症候群 / ヘリカーゼ / ホリデイジャンクション / タンパク質 / DNA |
|---|
| Outline of Final Research Achievements |
Bloom syndrome is a rare cancer-predisposition disorder caused by mutations of the Bloom syndrome protein (BLM). In this study, structural and biochemical studies of human BLM helicase were performed. New information about the reaction mechanism of BLM helicase toward Holliday junction (a repair intermediate in the DNA double-stranded break repair) was obtained.
|
| Free Research Field |
構造生物学
|
