2015 Fiscal Year Final Research Report
Evaluation of cytotoxicity and control of protein aggregation in the amyloid fibril formation
| Project/Area Number |
25440027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Tottori University |
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Principal Investigator |
Kawata Yasushi 鳥取大学, 工学(系)研究科(研究院), 教授 (40177697)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZOBATA TOMOHIRO 鳥取大学, 大学院工学研究科, 准教授 (50263489)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | タンパク質 / アミロイド線維 / タンパク質凝集抑制 / 神経変性病 |
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| Outline of Final Research Achievements |
We clarified the characteristics and mechanism of amyloid fibril formation of neurodegenerative disease causative proteins, such as alpha-synuclein, SOD1, and A-beta peptide, at amino acid level. We also evaluated cytotoxicity of the molecular species during amyloid fibril or aggregates formation process in the presence or absence of anthocyanins. We found that anthocyanins suppressed amyloid fibril formation by bypassing the protein molecules to mediate formation of amorphous aggregates that are not harmful for cells.
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| Free Research Field |
生物学
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