Roles of ARFs in superoxide production and chemotaxis of neutrophil

2015 Fiscal Year Final Research Report

• Project/Area Number: 25440051
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Hokkaido University (2014-2015); University of Occupational and Environmental Health, Japan (2013)
• Principal Investigator: MAZAKI Yuichi 北海道大学, 医学(系)研究科(研究院), 講師 (60311304)
• Co-Investigator(Renkei-kenkyūsha): SABE Hisataka 北海道大学, 医学研究科, 教授 (40187282)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 好中球 / 遊走

Outline of Final Research Achievements

Neutrophils are important in innate immunity and in the initiating an acute response to infection. During such a response, neutrophils migrate towards invaders and produce antimicrobial agents, including many reactive oxygen species. Previously, we reported that ARF regulatory factors, which are membrane trafficking protein, are involved in superoxide production and chemotaxis of neutrophils. In this study, we examined roles of ARFs in superoxide production and chemotaxis of neutrophil. Our results suggest that ARF1 is involved in subcellular localization of Rac1 during chemotaxis.

Free Research Field

細胞生物学