2015 Fiscal Year Final Research Report
Analysis of the regulation of actin cytoskeleton remodeling through mechanotransduction in endothelial cells and epithelial cells
| Project/Area Number |
25440076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | メカノシグナル / RhoGEF / アクチン骨格 / 血管内皮細胞 / 上皮細胞 / Rho |
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| Outline of Final Research Achievements |
In this study, we found 11 Rho-GEFs, which are upstream activator of Rho family small GTPases, involved in cyclic stretch-induced cell orientation in vascular endothelial cells. We focused on Solo, which is one of those Rho-GEFs, and found that Solo is required to orient the cells in response to the force derived from cadherin-based cell-cell adhesion. We also showed that Solo is required to activate RhoA and the formation of stress fibers by tensile-force application in epithelial cells.
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| Free Research Field |
分子細胞生物学
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