2015 Fiscal Year Final Research Report
RNA recognition by mRNA export receptor subunit p15
| Project/Area Number |
25440083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
Jun Katahira 大阪大学, 医学(系)研究科(研究院), 准教授 (30263312)
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| Research Collaborator |
Dimitrova Lyudmila
Hurt Ed
Aibara Shintaro
Stewart Murray
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 核－細胞質間輸送 / 遺伝子発現制御 |
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| Outline of Final Research Achievements |
The aim of this study is elucidation of the molecular mechanism of “cargo” mRNA recognition by the nuclear export receptor Tap-p15 heterodimer. We have shown that three distinct domains of Tap including RRM-LRR-NTF2L heterodimerized with p15 are involved in the cargo mRNA recognition. The results suggest that the Tap-p15 heterodimer recognizes bulk cellular mRNAs and viral constitutive transport element (CTE)-containing mRNA by differentially using these distinct RNA binding domains.
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| Free Research Field |
細胞生物学
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