Reguratory mechanism of TOR Complex 2 on glucose stimuli

2016 Fiscal Year Final Research Report

• Project/Area Number: 25440086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Tatebe Hisashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (00596819)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: TOR

Outline of Final Research Achievements

The TORC2 - Akt pathway is evolutionarily conserved from yeast to human. Whereas the human TORC2 pathway responds to insulin stimuli, the TORC2 pathway in a unicellular organism fission yeast directly responds to glucose in the extracellular environment. In the previous study, we utilized fission yeast as a model organism and found that Ryh1, a known activator of TORC2, is involved in glucose response of fission yeast TORC2.
In this study, we have discovered a novel mechanism that regulates TORC2 on glucose stimuli independently of Ryh1, although the precise molecular mechanism has remained to be elucidated. We have also revealed a key molecular mechanism how TORC2 activates Akt.

Free Research Field

細胞内シグナル伝達