Mechanism of nucleolar formation and its nutritional stress response

2015 Fiscal Year Final Research Report

• Project/Area Number: 25440089
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kumamoto University
• Principal Investigator: Saitoh Noriko 熊本大学, 発生医学研究所, 准教授 (40398235)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 核小体 / 細胞核構造 / 画像解析 / ハイコンテントスクリーニング

Outline of Final Research Achievements

The eukaryotic cell nucleus provides a three dimensional space for regulation of genomic DNA, and thus contains various nuclear architectures. The nucleolus, one of the largest nuclear domains is a site of ribosome biogenesis. It also plays roles in cellular energy homeostasis, response to cell stresses including nutritional deprivation, and cell proliferation regulation. In this study, my research group performed high content screening to identify factors involved in nucleolar formation and maintenance, and further analyzed their molecular functions to elucidate the nucleolar structure and function.

Free Research Field

細胞分子生物学