2015 Fiscal Year Final Research Report
Protein kinases ROCK -Developments of isoform-specific inhibitors and a method to detect active ROCK isoforms
| Project/Area Number |
25440091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
Yoneda Atsuko 東京薬科大学, 生命科学部, 助教 (80590372)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 蛋白質リン酸化酵素 / ROCK / がん / 細胞骨格 / 細胞運動 / 細胞外マトリクス |
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| Outline of Final Research Achievements |
Specific functions of two homologous protein kinases ROCK in tumor progression was needed to be revealed. This study found that a peptide derived from a ROCK2 specific endogenous inhibitor, CRMP2L, alone is capable of inhibiting cell migration and invasion of colon carcinoma cells, and that GSK3 phosphorylation of CRMP2L regulates inhibition of ROCK-dependent colon carcinoma cell migration/invasion by CRMP2L.
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| Free Research Field |
細胞生物学
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