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2015 Fiscal Year Final Research Report

Protein kinases ROCK -Developments of isoform-specific inhibitors and a method to detect active ROCK isoforms

Research Project

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Project/Area Number 25440091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cell biology
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Yoneda Atsuko  東京薬科大学, 生命科学部, 助教 (80590372)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords蛋白質リン酸化酵素 / ROCK / がん / 細胞骨格 / 細胞運動 / 細胞外マトリクス
Outline of Final Research Achievements

Specific functions of two homologous protein kinases ROCK in tumor progression was needed to be revealed. This study found that a peptide derived from a ROCK2 specific endogenous inhibitor, CRMP2L, alone is capable of inhibiting cell migration and invasion of colon carcinoma cells, and that GSK3 phosphorylation of CRMP2L regulates inhibition of ROCK-dependent colon carcinoma cell migration/invasion by CRMP2L.

Free Research Field

細胞生物学

URL: 

Published: 2017-05-10  

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