2015 Fiscal Year Final Research Report
Studies on molecular bases that control intracellular localization of the proteasome
| Project/Area Number |
25440093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Konan University |
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Principal Investigator |
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| Research Collaborator |
Aono Soma
Suzuki Natsumi
Tanaka Kizuki
Yamashita Daichi
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | タンパク質分解 / シグナル伝達 |
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| Outline of Final Research Achievements |
The aim of this research is to elucidate the molecular mechanisms that control intracellular localization of the 26S proteasome, using the fission yeast Schizosaccharomyces pombe as a model. In S. pombe, the main regulator of the localization of the proteasome is Cut8 protein and therefore we tried to find factors interacting with or regulating Cut8. Although we have not identified novel factors regulating the proteasome localization cooperating with Cut8, we could obtain several interesting results about the relationship between evolutionally conserved Greatwall-endosulfine pathway and Cut8 functions.
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| Free Research Field |
細胞生物学
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