2015 Fiscal Year Final Research Report
Specification of sensory primordia in cephalic ectoderm
| Project/Area Number |
25440106
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 転写制御因子 / 感覚器原基 / 発現制御 / 細胞分化 / エンハンサー / Sox転写因子 / Sall4 / 転写抑制因子 |
|---|
| Outline of Final Research Achievements |
Sensory organ primordia are derived from the cephalic ectoderm, and specified through multiple progressive steps. The NOP1 enhancer is specifically active in nasal and otic placodes, which is regulated not only by synergistic activation of Sox2/9 and Sall4 but also by multiple repressions. Zeb1/2 and Snail1/2 zinc finger proteins could repress the NOP1 enhancer. The otic placode specific enhancer, Otic1 enhancer, is also regulated by synergistic action of Sox and Sall4. These results imply that the combination of cooperative action of Sox and Sall4 and repressions would be a key mechanism in the specification of sensory placodes.
|
| Free Research Field |
発生生物学
|
