Synergistic action of nectins and cadherins generates the mosaic cellular pattern

2015 Fiscal Year Final Research Report

• Project/Area Number: 25440107
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Kobe University
• Principal Investigator: Togashi Hideru 神戸大学, 医学(系)研究科(研究院), 助教 (90415240)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 組織形成 / 細胞接着

Outline of Final Research Achievements

We examined the self-organization mechanism underlying the cellular patterning. When the cells express different combination of nectins and cadherins, heterophilic trans-interaction between nectins preferentially recruits cadherin to heterotypic junctions, and the differential distributions of cadherins between junctions promote cellular intercalations, resulting in the formation of the mosaic pattern. These observations are confirmed by model cell systems, and various cellular patterns are generated by the combinatorial expression of nectins and cadherins. Collectively, the synergistic action of nectins and cadherins generates mosaic pattern, which cannot be achieved by a single mechanism.

Free Research Field

発生生物学