Bone remodeling process for the lateral line scale in zebrafish

2015 Fiscal Year Final Research Report

• Project/Area Number: 25440118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイエンス統合データベースセンター)
• Principal Investigator: Wada Hironori 大学共同利用機関法人情報・システム研究機構(新領域融合研究センター及びライフサイ, 新領域融合研究センター, 融合プロジェクト研究員 (70322708)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨リモデリング / 側線鱗 / ゼブラフィッシュ

Outline of Final Research Achievements

Bones are continuously renewed through a bone remodeling process in a homeostatic manner. Defects in the bone remodeling process cause bone diseases such as osteoporosis. To understand mechanisms of bone remodeling, we studied the development of lateral line scales in zebrafish. The lateral line canal system is located within scales (dermal bone) running under the skin. We demonstrated that canals originate from scales through a bone remodeling process. Moreover, we found that lateral line sensory organs are required for the formation of canals, suggesting the existence of mutual interactions between the neural tissue and surrounding connective tissues (Wada et al., 2014).

Free Research Field

発生生物学