2015 Fiscal Year Final Research Report
Comparative analyses of hepatic architectures of vertebrates with special attention paid to portal triad development
| Project/Area Number |
25440153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Shizuoka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 組織構築 / 多様性 / 胆管 / 肝前駆細胞 / ノッチ / 条鰭類 / 進化 / 脊椎動物 |
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| Outline of Final Research Achievements |
The hepatic architecture of vertebrates was classified into two types; portal triad-type with intrahepatic bile ducts running along portal veins, and non-portal triad-type with intrahepatic bile ducts independent of portal veins. The latter was observed in many actinopterygians, and the former was seen in other vertebrates, including agnathans, chondrichthyans and mammals. In a process of diversification of actinopterygians, the portal triad-type hepatic architecture gradually changed into the non-portal triad-type hepatic architecture. Fishes of Elopiformes had an intermediate hepatic architecture of both types. Amino acid sequences of Jag1, which is responsible for biliary induction in mammals, were comparatively analyzed among vertebrates with special attention paid to the hepatic architectures.
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| Free Research Field |
組織構築学
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