2016 Fiscal Year Final Research Report
Analysis of the construction of extracellular environment and regulation of morphogenesis by extracellular arylsulfatase
| Project/Area Number |
25440156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AKIMOTO Yoshihiro 杏林大学, 医学部, 教授 (60184115)
YASUMASU Shigeki 上智大学, 理工学部, 教授 (00222357)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 細胞外基質 / アリールスルファターゼ / 分子環境 / 形態形成 |
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| Outline of Final Research Achievements |
To elucidate the role of arylsulfatase B (ArsB) as a component of the extracellular matrix, distribution pattern of ArsB in medaka brain was examined immunohistochemically using light and electron microscopy. The fine morphology of the cells that express ArsB was also analyzed at the ultrastructural level. The ArsB mutants were generated to analyze the phenotypes. ArsB signals were observed both in the intracellular and extracellular spaces of the choroid plexus of the third ventricle. Weak signals were additionally detected in the restricted cells of ependyma constituting the floor of the fourth ventricle. It is possible that extracellular environment including ArsB is constructed depending on the cerebrospinal fluid circulation.
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| Free Research Field |
発生生物学
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