2015 Fiscal Year Final Research Report
Regulation of folliculegenesis by brain/gut peptides in Ciona intestinalis
| Project/Area Number |
25440161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Suntory Foundation for Life Sciences |
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Principal Investigator |
Satake Honoo 公益財団法人サントリー生命科学財団, その他部局等, 主幹研究員 (20280688)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWADA Tsuyoshi 公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主席研究員 (90300821)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ペプチド / カタユウレイボヤ / 卵胞成長 |
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| Outline of Final Research Achievements |
In this study, we identified a receptor for Ci-GALP, which is an Ciona intestin ortholog of vertebrate galanin/GALP. We also localized the mRNA ofreceptors for Ci-GALP, cionin, and GrRH, respectivly. RNA-Seq follwed by real-time PCR for the Ciona follicles treated with each peptide revealed the gene expression profile. Moreover, the inhibitors of the regulated gene product suppress follicle grwoth in a ligand-specific manner. Taken together, these results substantiated the essentila molecular mechanisms of Ciona follicle grwoth regulated bu brain/gut peptides. These are the first reports on the biological roles of these brain/gut peptide in the ovary in an organism.
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| Free Research Field |
内分泌、進化生物学
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