2015 Fiscal Year Final Research Report
Prostagladin protects neurons in hibernation
| Project/Area Number |
25440174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Hirofumi 福岡教育大学, 教育学部, 教授 (20304694)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 冬眠 / 視床下部 / プロスタグランジン |
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| Outline of Final Research Achievements |
Low temperature increased numbers of pERK (one of markers to detect reactive neurons to stress) immunoreactive neurons in the mouse hypothalamic paraventricular nucleus. This result suggests that the hypothalamus is one of brain areas where cope with low temperature stress. These hypothalamic neurons also contained E2 (one of prostaglandin receptors) immunoreactive structures that suggests that prostaglandin affects the hypothalamic paraventricular neurons. Getting together, low temperature stress may be sensed in the hypothalamus where prostaglandin probably functions as a neurotransmitter and/or neuromodulator affecting the hypothalamus.
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| Free Research Field |
神経解剖学
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