2016 Fiscal Year Final Research Report
Regulation and role of the arachidonate cascade reaction at different life stages of adipocytes
| Project/Area Number |
25450128
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
JISAKA Mitsuo 島根大学, 生物資源科学部, 准教授 (60243424)
NISHIMURA Kohji 島根大学, 生物資源科学部, 助教 (30304257)
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| Research Collaborator |
SHONO Fumiaki
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | prostaglandin / prostacyclin / adipocyte / adipogenesis / IP receptor / life stage / PGI2 / preadipogenic cells |
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| Outline of Final Research Achievements |
This study was undertaken to study the regulatory mechanisms of biosynthesis of prostaglandin (PG) I2 called prostacyclin and specific action of its agonists and antagonists in cultured adipocytes at different life stages of adipogenesis including growth, differentiation, and maturation phases. These results revealed the stimulatory effects of endogenous and exogenous PGI2 and the agonists for the IP receptor on cultured preadipogenic cells as well as the suppression by the IP antagonists at differentiation and maturation phases. The findings provided the evidence for the specific and unique roles of prostacyclin in the control of adipogenesis in cultured adipocytes.
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| Free Research Field |
応用生物化学
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