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2015 Fiscal Year Final Research Report

Elucidation of catalytic mechanisms of thermostable glycoside-hydrolases by structural analyses

Research Project

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Project/Area Number 25450143
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

MIne Shouhei  国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (70415751)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsグルコサミン / 好熱菌 / 酵素
Outline of Final Research Achievements

Chitin is a polysaccharide that comprises a major constituent of fungal cell walls, the exoskeletons of insects, and the shells of crustaceans. N-acetylglucosamine (GlcNAc) and Glucosamine (GlcN), which is derived from the hydrolysis of chitin or chitosan,have a variety of biological functions and have therefore been used as a food additive and in medicines. Using the chitin catabolic pathway of hyperthemophilie,we have focused two thermostable enzymes, deacetylase (Dac) (EC 3.5.1.-) and β-N-acetylglucosaminidases (NagA) (EC 3.2.1.52). To understand the catalysis and adaptation to extreme high temperature of these enzymes, we have determined the structures of Dac and NagA.

Free Research Field

構造生物学

URL: 

Published: 2017-05-10  

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