Synthetic and structural studies of natural antibiotics which have potent activities against drug resistance strains

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450147
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioorganic chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIGAMI Ken 東京大学, 農学生命科学研究科, 准教授 (70292787)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 有機化学 / 天然物化学 / 立体化学 / 抗菌活性 / 薬剤耐性 / glabramycin / Majusculoic acid / 抗ピロリ菌

Outline of Final Research Achievements

Synthetic studies on natural products, which could be new drugs against drug-resistant strains, were carried out. About a sesquiterpene, which is a potent inhibitor of H. pylori growth, we examined optimization of racemic synthesis and synthesis of a substrate for optical resolution employing our tandem radical cyclization strategy. Concerning glabramycins, which are potent inhibitor against Staphylococcus aureus, we succeeded Structural revision of glabramycin B was achieved by enantioselective synthesis of our proposed structure. We also suggest the absolute configuration of Majusculoic acid, a novel antifungal drug, by synthesis of enantiomer of the natural product, although some problems in several steps have been still remained.

Free Research Field

農学