Exploitation of caloric restriction mimetics from rare sugars and their deoxy derivatives

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioorganic chemistry
• Research Institution: Kagawa University
• Principal Investigator: Sato Masashi 香川大学, 農学部, 教授 (20263890)
• Co-Investigator(Kenkyū-buntansha): YOSHIHARA AKIHIDE 香川大学, 農学部, 助教 (40548765)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 希少糖 / カロリー制限模倣物質 / 抗老化 / 線虫

Outline of Final Research Achievements

The aim of this study is to explore calorie restriction mimetics (CRM) from deoxy derivatives of monosaccharides (deoxy rare sugars). We enzymatically synthesized various deoxy rare sugars including 1- and 6-deoxy derivatives of ketohexoses, and 6-deoxy derivatives of aldohexoses. These deoxy rare sugars were subjected to preliminary screening by evaluating growth inhibition activity against the nematode Caenorhabditis elegans. As a result, a deoxy rare sugar exerted strong inhibition activity. The deoxy rare sugar also extended C. elegans lifespan. These results indicate that the deoxy rare sugar is a candidate CRM.

Free Research Field

生物活性化学