2015 Fiscal Year Final Research Report
Role of GLP-1 during the development of diet-induced obesity and glucose impairment
Project/Area Number |
25450159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Hokkaido University |
Principal Investigator |
HIRA Tohru 北海道大学, (連合)農学研究科(研究院), 講師 (10396301)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | GLP-1 / 食事誘導性肥満 / 食後血糖 |
Outline of Final Research Achievements |
It is unclear how postprandial GLP-1 secretory response is affected during the development of diet-induced obesity. Meal tolerance test (MTT) was conducted in rats fed normal or high-fat/high-sucrose (HF/HS) diet, and postprandial GLP-1, insulin and glycemic response were monitored. Postprandial GLP-1 secretion was larger in HF/HS rats than control rats at week 2 and 4, and this was reflected by increased insulin response in HF/HS rats. In the intestinal mucosa, among various nutrient sensing receptors and transporters evaluated, one of fatty acid receptors, FFAR1 had higher mRNA expression in the upper small intestine of HF/HS rats compared to that of control rats. These result demonstrates that postprandial GLP-1 secretion is increased in the early period of developing diet-induced obesity, and that increased postprandial GLP-1 response contributes to normalize postprandial glycemic response by enhancing insulin secretion.
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Free Research Field |
食品栄養学
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