Study on mechanism for anti-allergic effect of hydrolyzable tannin in rugosa rose petals

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450160
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Kitami Institute of Technology
• Principal Investigator: ARAI HIROFUMI 北見工業大学, 工学部, 准教授 (70295848)
• Co-Investigator(Kenkyū-buntansha): YAMADA Koji 崇城大学, 生物生命学部, 教授 (60158186)
• Co-Investigator(Renkei-kenkyūsha): YAMAGISHI Takashi 北見工業大学, 工学部, 特任教授 (80271758)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アレルギー / ポリフェノール / タンニン / テリマグランジン / ヒスタミン / ロイコトリエン

Outline of Final Research Achievements

It is known that about 30% of Japanese people have any allergy diseases. Immediate hypersensitivity such as hay fever is induced by mast cells which are stimulated through the antigen-antibody reaction. In the present study, we investigated effects of hydrolyzable tannins in Rugosa rose petals on the allergic reaction in mast cells using cell lines.
Tellimagrandin I, a kind of hydrolyzable tannin in Rugosa rose petals, suppressed the chemical mediator release from the stimulated mast cells. Moreover, tellimagrandin I inhibited the phosphorylation of protein kinases and calcium influx in mast cells. These results suggest that tellimagrandin I may have the anti-allergic function.

Free Research Field

食品機能学