Research on the regulation of dietary carbohydrate level during pregnancy for improvement of life style diseases in second generation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Chiba University
• Principal Investigator: HIRAI SHIZUKA 千葉大学, 園芸学研究科, 助教 (90432343)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 妊娠期低栄養 / 糖質制限 / 肥満 / 糖・脂質代謝 / インスリン抵抗性 / 不安様行動 / 精神疾患

Outline of Final Research Achievements

In the present study, I examined the mechanism that carbohydrate restriction during pregnancy does not exacerbate glucose and lipid metabolism induced by high fat diet in mice offspring. Carbohydrate restriction did not promote the expression of fatty acid synthesis-related genes and improved insulin sensitivity via increasing small-sized white adipocytes.
I also examined the relationship between intrauterine undernutrition and development of psychiatric disorder. Offspring of total energy restriction group had higher stress sensitivity and showed anxiety-like behavior, but which was alleviated in the offspring of carbohydrate restriction group.

Free Research Field

栄養生化学