2016 Fiscal Year Final Research Report
Analysis of a novel lipid metabolism-related gene derived from high-fat diet induced fatty liver mouse.
| Project/Area Number |
25450166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HORIO FUMIHIKO 名古屋大学, 大学院生命農学研究科, 教授 (20165591)
MURAI ATSUSHI 名古屋大学, 大学院生命農学研究科, 准教授 (10313975)
ODA HIROAKI 名古屋大学, 大学院生命農学研究科, 准教授 (20204208)
OHNO TAMIO 名古屋大学, 大学院医学系研究科, 准教授 (90293620)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 脂肪肝 / 高脂肪食 / ノックアウト / 遺伝解析 / 脂質代謝 |
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| Outline of Final Research Achievements |
We previously identified fatty liver susceptible locus (Fl1sa) on mouse chromosome 12 in SMXA-5 mice, a model of high-fat induced fatty liver. We selected Iah1 gene as a candidate gene for Fl1sa. To clarify the relation between Iah1 gene and fatty liver, we constructed the Iah1 gene knockout mice. Liver lipids contents in Iah1 gene knockout mice were lower than that in WT mice. This study suggested that the low expression level of Iah1 led to the accumulation of lipids in liver.
In addition, we found that mice having the large insertion/deletion in upstream of Iah1 gene showed low level of Iah1 gene expression.
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| Free Research Field |
栄養生化学
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