2015 Fiscal Year Final Research Report
Precise analysis of pseudovitamin B12 compounds in food and effect of these compounds on vitamin B12 status of living cells
| Project/Area Number |
25450168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ビタミンB12 / 神経障害 / 欠乏症 / 擬似ビタミン / 貝類 / 藻類 / キノコ類 / 乳類 |
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| Outline of Final Research Achievements |
Foods derived from animals, namely fish, shellfish, and milk, are considered major dietary sources of vitamin B12 (B12). When food corrinoids were characterized using liquid chromatography-electrospray ionization/tandem mass spectrometry, certain food items (edible cyanobacteria and snails) contained pseduo B12 inactive in humans. Intrinsic factor involved in the gastrointestinal absorption of B12 preferentially bind B12 in the presence of pseudoB12 under physiological conditions. PseudoB12 did not function as cofactors of B12-depedent enzymes of COS7 cultured cells. These results suggest that pseudoB12 does not have the ability to act as a B12 antagonist in mammals.
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| Free Research Field |
食品栄養科学
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