Physiological funcition of flavonoid metabolites in bile

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: Hashimoto Naoto 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 上級研究員 (20414758)
• Co-Investigator(Kenkyū-buntansha): Han Kyu-Ho 帯広畜産大学, 畜産学科, 准教授 (50553450)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アントシアニン / 中性脂肪 / 胆汁 / 胆石 / ラット / コレステロール

Outline of Final Research Achievements

Flavonoids are rich in fruits and vegetables. Flabonoids after absorption into the body are metabolized and mainly excreted via bile which abundantly contains various lipids. Howevwe, influence of biliary flavonoid metabolites on the biliary lipid profiles are not well-studied. In this study, we investigated the influence of flavonoids on biliary composition in rats and mice. In rats given one-shot administration of anthocyanin, biliary triglyceride (TG) increased and hepatic TG content subsequently decreased, whereas in rats given quercetin, biliary lipids except but TG were totally reduced. A black soybean seed coat extract, which abundantly contains anthocyanin, lowered excretion of cholesterol into bile and tended to prevent gallstone formation.

Free Research Field

食品栄養学