Role of cell-mediated immunity in the protection against nocardiosis and mycobacteriosis in fish

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Aquatic life science
• Research Institution: Kagoshima University
• Principal Investigator: Araki Kyosuke 鹿児島大学, 農水産獣医学域水産学系, 助教 (30409073)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ノカルジア症 / ミコバクテリア症 / 細胞性免疫 / ワクチン / ブリ / カンパチ / IL-12 / IFNgamma

Outline of Final Research Achievements

In this project, we showed 1) interferon-γ and interleukin-12 which are related to the cell-mediated immunity, play a crucial role in the protection against Nocardia seriolae infection in amberjack, 2) interleukin-10 is related to induction of humoral immune response against Nocardia seriolae infection, 3) IL-12 is a promising adjuvant for inactivated vaccine against Nocardiosis in amberjack, 4) 6 kDa early secretory target (ESAT-6) and 10 kDa culture filtrate protein (CFP-10) from Mycobacterium sp. have a potential for the protective antigen against Mycobacterium sp. infection in fish.

Free Research Field

魚類免疫学