2015 Fiscal Year Final Research Report
Possible countermeasures against age-associated deteriorations of bovine oocytes
| Project/Area Number |
25450400
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 加齢 / 卵子 / ミトコンドリア / 卵胞液 / 顆粒層細胞 |
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| Outline of Final Research Achievements |
Present study investigated casual factors of the age associated deterioration of oocytes by using cows as a model animal, and showed that granulosa cells and follicular fluids of aged cows induced dysfunctions of oocytes. Results obtained in this study suggest that given granulosa cells and follicular fluid are replaced with those derived from younger cows, developmental competence of the oocytes derived from aged cows would improve. In addition, present study demonstrated the presence of mitochondrial quality control system in oocytes, through which oocytes replenish mitochondria in response to induced mitochondrial dysfunctions. In addition, present study showed that resveratrol induced mitochondrial replenishment by enhancing mitochondrial quality control system.
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| Free Research Field |
動物生殖学
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