Mechanism of IgA-mediated cross protection induced by mucosal immunization

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHIDA Reiko 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (80435966)
• Co-Investigator(Renkei-kenkyūsha): TAKADA Ayato 北海道大学, 人獣共通感染症リサーチセンター, 教授 (10292062)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 粘膜免疫 / インフルエンザウイルス / IgA / 交差感染防御

Outline of Final Research Achievements

Mucosal immunization with influenza virus vaccine confers cross-protection against infection with influenza virus antigenic variants as well as multiple subtypes of influenza A viruses. In this study, we found that many cross-reactive but non-neutralizing anti-HA IgA antibodies are produced in the upper respiratory tract of immunized mice. These anti-HA IgA antibodies showed stronger antiviral activities against influenza A viruses than IgG antibodies. Particularly, the results from this study suggest that the inhibition of virus particles release from the infected cell surface may be one of the IgA-mediated protective mechanisms important for heterosubtypic immunity.

Free Research Field

ウイルス学