2015 Fiscal Year Final Research Report
Development of vaccines against leishmaniasis using polyvalent CDV vaccine and cytokine adjuvant.
| Project/Area Number |
25450421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO HIROKI 東京大学, 医科学研究所, 助教 (50418654)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | イヌジステンパーウイルス / リーシュマニア / 二価ワクチン |
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| Outline of Final Research Achievements |
Leishmaniasis is one of the six major tropical diseases documented by WHO. Leishmaniasis is caused by infection with parasite protozoa Leishmania, and dogs harboring Leishmania act as reservoirs. There is presently no vaccine against leishmaniasis.
We generated recombinant canine distemper viruses (rCDVs) that express Leishmania antigens or Th1 cytokine, and evaluated their protective efficacy against Leishmania challenge. As a result, the cocktail of three rCDVs expressing different antigens showed significant vaccine efficiency.
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| Free Research Field |
ウイルス学
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