2016 Fiscal Year Final Research Report
Development of Microminipig model of atherosclerosis for medical device development
| Project/Area Number |
25450426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IZUMI Yasukatsu 大阪市立大学, 医学(系)研究科(研究院), 准教授 (10347495)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 動脈硬化モデル動物 / ミニブタ / 高脂肪高コレステロール食 |
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| Outline of Final Research Achievements |
We established a model of atherosclerosis in the Microminipig by giving animals a high fat and high cholesterol diet for 8 weeks. The aim of this study is to induce atherosclerosis which can be confirmed by a clinical imaging test for short period using the previous our model. This study added angiotensin II for 2 weeks or NOS inhibitor for 8 weeks to the above diet control. The addition of angiotensin II and NOS could induce accelerated atherosclerotic lesions of systemic aorta and arteries for while the atherosclerotic lesions (ex. intima thickening) were not recognized by carotid artery echo. Model improvement or consideration of evaluation method (ex. CAVI: Cardio Ankle Vascular Index) will be needed in the future.
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| Free Research Field |
実験病理学
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