2015 Fiscal Year Final Research Report
Analysis of the mechanism of Oocyst formation: construction of newly strategy for malaria prevention
| Project/Area Number |
25450430
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
Ikadai Hiromi 北里大学, 獣医学部, 准教授 (80327460)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | マラリア原虫 / オーシスト / 遺伝子欠損 |
|---|
| Outline of Final Research Achievements |
Using a combination of genetic analysis and functional studies in the rodent malaria model Plasmodium berghei, we identified five oocyst capsule proteins (PbCaps) and four ookinete expression proteins of conserved Plasmodium proteins. Moreover, we report on the characterization of two PbCaps (PbCap 93 and 494). Genetic analysis indicates that the gene is essential and that two PbCaps(-) mutant parasites form oocysts in decreased numbers. Targeting of the oocyst capsule may provide a new strategy for malaria control.
|
| Free Research Field |
寄生虫学
|
