2016 Fiscal Year Final Research Report
Analyses of energy metabolism adapted to a low oxygen environment in developmental stages of Eimeria
| Project/Area Number |
25450436
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Veterinary medical science
|
|---|
| Research Institution | Osaka Prefecture University (2015-2016)
National Agriculture and Food Research Organization (2013-2014) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Keywords | コクシジウム / 呼吸鎖 / 低酸素 / ミトコンドリア |
|---|
| Outline of Final Research Achievements |
Control of chicken coccidia is important issue in poultry industry. The object of this study is focused on producing the safe and new anti-coccidiostat. Consequently, we successfully constructed the methods of purification of Eimeria tenella mitochondria and assay system of the mitochondria activity. Using the systems, we could found some compounds could inhibit the activities in vitro. Furthermore, these compounds could kill the purified sporozoites and merozoites. These results can show utility for clarifying the respiratory chain activity of Eimeria spp. and finding seed compounds against the parasites.
|
| Free Research Field |
寄生虫学
|
