Investigation of pathological mechanisms for diagnostic and treatment strategy of glomerulonephropathy in dogs and cats

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450446
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Kagoshima University
• Principal Investigator: Yabuki Akira 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (10315400)
• Co-Investigator(Renkei-kenkyūsha): YAMATO OSAMU 鹿児島大学, 農水産獣医学域獣医学系, 教授 (80261337) ; ICHII OSAMU 北海道大学, 獣医学部, 准教授 (60547769)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 犬 / 糸球体腎症 / 免疫複合体糸球体腎炎 / 病態機序

Outline of Final Research Achievements

The aim of the present study was to clarify the pathological mechanisms of glomerulonephropathy in dogs and cats, especially in dogs. In pathologically, interstitial fibrosis was closely related with the deterioration of renal functions. Changes of several factors including carbohydrate chains, nephrin, and ghrelin were demonstrated in the cases with glomerulonephropathy, especially immune-complex mediated glomerulonephritis (ICGN). However, no common changes were detected in the course of ICGN, and this finding was thought to be reflected the complexity of pathological changes and clinical features of this disease.

Free Research Field

獣医臨床病理学